Sodium vitrate is increasingly used in the clinical treatment of osteoarthritis and can significantly improve patients’ symptoms such as dyskinesia, joint pain, joint effusion and morning stiffness. Studies have concluded that sodium hyaluronate is no less than a preferred agent for the treatment of osteoarthritis and is recognized by an increasing number of clinical experts. The efficacy analysis of sodium hyaluronate in the treatment of knee osteoarthritis concluded that sodium hyaluronate is effective in the treatment of knee 0A. The efficacy of sodium hyaluronate is obvious, and the smaller molecular weight of sodium hyaluronate can achieve a better clinical effect earlier, and the long-term application also has a better clinical effect, and the incidence of adverse reactions is extremely low, which is safer and more effective. Tao Hairong of the Department of Orthopedics, North Hospital of the Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, showed that patients were treated with joint cavity injection of sodium hyaluronate once/week for 5 weeks, and 6 indexes of joint pain, swelling, pressure pain, mobility and walking were rated before and after treatment, each of which was rated at 4 levels. The results were excellent in 9 cases, good in 5 cases and acceptable in 2 cases. Intra-articular injection of sodium hyaluronate is considered a safe and effective method for the treatment of RA. The efficacy of sodium hyaluronate was related to the stage of progression of RA disease. For patients with early RA, after systematic anti-rheumatoid therapy, if the lesion is limited to unilateral or bilateral knee joints, joint cavity lavage with sodium hyaluronate injection can achieve relatively satisfactory results, while for patients with severe synovial hyperplasia and partial destruction of articular cartilage in the middle stage or above, open synovectomy should be performed as soon as possible to save joint function. The literature study found that the effective rate of treatment reached 88% in 468 patients. In contrast, the control group was only 34%. Sodium vitreous acid products on the market nowadays, such as SPECTRO, have good clinical application. In the treatment of osteoarthritis of the knee with SPRIT injection, the total effective rate was 96 3% after 5 weeks, with no obvious toxic side effects. After stopping the drug for 16 months, 74.0% of the patients had no recurrence. The results showed that although the efficacy of the sodium vitreous acid treatment group was 1-2 d later than that of the steroid group, the degree of relief of joint symptoms in the two groups was basically the same, and the maintenance time was significantly longer in the sodium vitreous acid group than in the steroid group. Other controlled trials have concluded that the efficacy of sodium hyaluronate treatment can last up to 1 year. In conclusion, sodium hyaluronate is effective in the treatment of osteoarthritis, with a high safety profile and few adverse effects. With further research on its basic research and further research on its compounding, it is believed that its application in medicine will have a broader prospect. This article is authorized by Dr. Tao Hailong.