Submandibular lymph node enlargement and pressure pain, common causes for infection, tumor factors, need to clarify the specific causes and then targeted treatment. 1. Infection: Bacteria and viruses attack the local lymph nodes, resulting in lymph node enlargement and submandibular lymph node enlargement and tenderness. Through history taking, physical examination and ultrasound, blood tests, etc., to clarify the infection situation, choose sensitive antibiotic drugs to fight infection. For example, penicillin, cephalosporin and so on. In the course of treatment, it can be combined with non-steroidal anti-inflammatory drugs to improve the pain symptoms. 2. Tumor: common lymphoma, malignant tumor metastatic cancer and other conditions, patients may also appear submandibular lymph node swelling and pressure pain. It is necessary to clarify the type of lesion and primary lesion through pathological examination, and surgical treatment should be the main treatment to remove the lesion and reduce the influence of the lesion on the patient. After surgery, radiotherapy, targeted drug therapy and other measures should be assisted to control and stabilize the disease. Commonly used drugs include interferon, monoclonal antibody rituximab, etoposide, flexibacter and so on. Therefore, it is recommended that patients seek early medical treatment to confirm the diagnosis of the lesion and active treatment to reduce the impact of the lesion on the patient, the drug should be applied under the guidance of the doctor.