A high white blood cell count of 100 x 10^9/L is a very serious value, commonly seen in acute and chronic leukemia. Hyperleukocytemia is most commonly seen in acute and chronic leukemia, a hematologic malignancy. When the leukocyte count in the circulating blood is greater than 100 x 10^9/L, the patient may develop leukocytosis, which is manifested by respiratory distress, unresponsiveness, slurred speech, hypoxemia, and intracranial hemorrhage, which may be manifested by the coexistence of thromboembolism and hemorrhage. Leukocytoclastosis may increase early mortality in leukemia patients and is relatively severe, requiring urgent management. Currently, leukemia cells can be removed by single harvesting using a blood cell separator, along with hydration and chemotherapy (hydroxyurea). It is also necessary to prevent complications such as acidosis (sodium bicarbonate injection) and electrolyte disturbances caused by leukolysis. When the white blood cell count is 100 x 10^9/L, it is recommended to seek prompt medical attention and standardize the treatment under the guidance of a medical professional.