OverviewIt is an interphalangeal neuroma that can cause chronic irritation and inflammation. Inferior and lateral pressure can lead to sustained compression of the toe nerves, with the toe nerves between the 3rd and 4th toes being the most susceptible to involvement. Predisposing factors for the development of Morton’s neuroma include: occupations that involve prolonged standing, where the metatarsophalangeal joints are continually stretched; hammertoes; bunions and high-heeled feet. On examination, intermetatarsal head tenderness is most pronounced; the metatarsophalangeal joint squeeze sign is positive; passive movement of the joint is painless; and in severe cases, there is loss of sensation between the 2 adjacent toes. Diagnosis of local nerve block can be clear. Treatment recommendations Wear wide shoes; soft insoles; intertoe placeholder; avoid unnecessary weight-bearing exercise; reduce stride length when walking; local block. Surgery may be considered if symptoms persist for more than 3 months.