Creatinine is a product of muscle metabolism in the body, which is mainly excreted by glomerular filtration. The source of creatinine in the blood consists of two parts: exogenous creatinine ingested from food and endogenous creatinine produced in the body. Therefore, creatinine a little higher than normal value may be physiological factors (eating a lot of meat food, muscular people, etc.), but it may also be a kidney disease, need to be analyzed specifically. 1. Physiological factors: eating a lot of meat, strenuous exercise, muscular people, etc. can be manifested as relatively high creatinine value, at this time no special treatment, light diet, pay attention to rest, and regular monitoring of creatinine level can be. 2. Kidney disease: Kidney disease such as renal insufficiency, due to renal excretory function decreases, creatinine excretion decreases, there will be an increase in blood creatinine level, but also can be accompanied by edema, vomiting and other symptoms, if necessary, such as renal puncture test can assist in the definitive diagnosis. Creatinine higher than the normal value of a little bit of advice in a timely manner to the regular hospital to find out the reasons, follow the doctor’s instructions for treatment, so as not to delay the condition.