Every time I wake up with a sore throat, it is mainly seen in the following people: 1. Patients with obstructive sleep apnea hypoventilation, due to poor nasal ventilation, narrow oropharyngeal cavity, hypertrophy of the tongue, or the patient’s body size is fat, resulting in the air not being moistened through the nasal cavity during sleep, but inhaled directly through the oropharynx, leading to dryness of the pharyngeal mucosa. The long-term dryness of the mucous membrane of the pharyngeal cavity can easily lead to inflammation and ulceration of the pharyngeal mucosa.2. It may be related to the environment in which the patient sleeps, such as the weather is very dry and the humidity of the air is particularly low, and the patient is prone to a dry throat in the morning when he wakes up. Especially in the north, in winter, the house has floor heating, heating, etc., or with air conditioning, it is also easy to have this situation. Some patients themselves have chronic tonsillitis and chronic pharyngitis, which may be aggravated by cold and other factors during nighttime sleep, resulting in the manifestation of pharyngitis and sore throat in the morning when they wake up.