Oxycodone Hydrochloride Extended-Release Tablets are available in 5mg, 10mg, 20mg, and 40mg sizes, with the maximum dosage for most patients being 200mg/12 hours, and the maximum clinically reported dosage being 520mg every 12 hours. Oxycodone Hydrochloride Extended-Release Tablets are commonly used pain medications that are primarily applied to severe pain. This medication is a long-acting pain reliever that is taken orally twice a day, every 12 hours. Oral administration of this medication should be applied in small doses and gradually increased. When the maximum dose is reached, attention should be paid to the presence of appropriate side effects. Exceeding the maximum dose may cause serious complications, among which respiratory depression may affect breathing and endanger life. Patients who still cannot achieve better pain relief with the maximum dose need to choose other pain medications, or pain relief methods, depending on the patient’s condition. Therefore, Oxycodone Hydrochloride Extended-Release Tablets above the maximum dose is unsafe and the pain relief method should be adjusted.