Viread, or tenofovir dipivoxil tablets, can be exchanged for entecavir, but there are a few points to note, such as entecavir side effects, entecavir needs to be taken on an empty stomach, etc. It is recommended to change the medication under the guidance of a doctor, and not to change the medication on your own. Tenofovir dipivoxil is mainly used for the treatment of HIV-1 infection and chronic hepatitis B. It may cause adverse reactions such as nausea, vomiting, diarrhea, dizziness and headache, malaise, and rash. The drug is contraindicated in people who are allergic to tenofovir dipivoxil. Entecavir is mainly used to treat chronic hepatitis B in adults with active viral replication and persistent elevation of serum alanine aminotransferase. Adverse reactions such as diarrhea, dyspepsia, nausea, dizziness and headache may occur with entecavir. The drug is contraindicated in case of hypersensitivity to entecavir. If replacing tenofovir with entecavir you need to be aware of the following points: 1. If the replacement is temporary and lasts for a few weeks or months there is nothing to be aware of. If the replacement is long-term, it is important to note that entecavir needs to be taken on an empty stomach and tenofovir does not. 2. If it is pregnancy, you can not replace tenofovir with entecavir, because entecavir has a greater reproductive toxicity, the original patient who is taking entecavir, if you replace entecavir with tenofovir 3 to 6 months in advance. Tenofovir dipivoxil can be replaced with entecavir, but it is recommended to replace it under the guidance of a doctor and not on your own. Drugs need to be applied appropriately according to the doctor’s instructions.