Schizophrenia is one of the most common and serious mental illnesses, often manifested by thinking, emotions and behaviors that do not match the outside world, and by a lack of coordination between their feelings, thoughts and behaviors and a more lax thinking. Patients often do not recognize their illness and therefore do not actively seek medical attention. Most patients with schizophrenia have an insidious onset, and intervals are also often abnormal or have residual symptoms. Patients sometimes have complaints of anxiety, but the internal experience is not obvious or intense. Patients with generalized anxiety disorder suffer from anxiety and tension and have somatic complaints such as dizziness, palpitations, tension headaches, insomnia, back pain, and muscle tension, and often seek medical attention everywhere. Careful questioning of the causes of anxiety symptoms can help reduce misdiagnosis, as patients with schizophrenia often expose peculiar thoughts, such as the perception of threatening influences around them and the belief that others’ every move is related to them. Therefore, the two are not difficult to identify through detailed history taking and psychiatric examination.