Nifedipine and felodipine are both very common clinical calcium antagonist antihypertensive drugs with very good antihypertensive effects. However, there are several differences, as follows: First, the onset of action time, nifedipine onset of action time is very fast, while felodipine relatively slower; Second, the impact on the heart, nifedipine in taking will cause heart rate increase and other adverse effects, while felodipine on the heart’s impact is very small; Third, the impact on heart failure, calcium antagonists will inhibit myocardial contraction, but the study found that nifedipine on myocardial contraction inhibition is stronger, so it can aggravate the symptoms of heart failure patients. inhibitory effect is stronger and therefore can aggravate the symptoms of heart failure patients. The effect of felodipine on heart failure patients is neutral, that is, it will not aggravate the symptoms of heart failure. d. If grapefruit juice is taken at the same time as the drug, it will not only increase the drug concentration of nifedipine, but also prolong the duration of drug action. But for felodipine will only increase the drug concentration, will not prolong the duration of drug action.