There is no accurate data on the cure rate of multidrug-resistant tuberculous pleurisy, but most of them can be recovered. Treatment of multidrug-resistant tuberculosis pleurisy mainly consists of anti-tuberculosis treatment and treatment of pleurisy, usually the disease can be cured after treatment, but recurrence is not excluded. The treatment of pleurisy includes nutrition, support, rest and symptomatic treatment. If the pleurisy leads to excessive pleural effusion, it needs to be pumped and treated, and glucocorticosteroids, such as prednisone, are used if necessary, and the general treatment time takes 4 to 6 weeks. Commonly used drugs for anti-tuberculosis treatment include isoniazid, rifampicin, ethambutol, kanamycin, moxifloxacin, etc. Drug sensitivity test is needed before using the drugs to choose the sensitive drugs, and the general treatment intensification period is 9 to 12 months, and the total treatment period is 20 months or longer, depending on the treatment effect. It is recommended to use the drugs under the guidance of a doctor.