1.hepatomegaly: more than 80% of patients have hepatomegaly, which is mostly caused by intrahepatic bile accumulation. 2.Gallbladder enlargement: If the cancer occurs below the confluence of the three ducts, the enlarged gallbladder can be palpated. 3. Ascites: in late stage, due to peritoneal invasion, or invasion of portal vein, resulting in portal hypertension, ascites may appear. In general, although jaundice is an obvious symptom of the disease, its correct diagnosis is often difficult and easily confused with common bile duct stones, especially before the appearance of jaundice is not easy to make a clear diagnosis, often requiring a comprehensive and careful examination and analysis of those with epigastric pain and discomfort or obstructive jaundice to make a more correct diagnosis, and in some cases, the truth can be clarified only after a caesarean section. In recent years, with the development and improvement of diagnostic imaging techniques, the rate of correct preoperative diagnosis has increased considerably, and it is important to select the appropriate tests in a timely manner for patients with suspicion so that early diagnosis and treatment of the disease can be made.