Wandering pain in the acute phase of AIDS may be related to AIDS, or it may be combined with arthritis, rheumatoid and other diseases, so it should cooperate with professional doctors to improve the systematic examination, and in addition to anti-HIV treatment, it should also target the treatment of arthritis, rheumatoid and other diseases. If the acute phase of AIDS itself causes generalized wandering pain, mainly anti-HIV treatment will be carried out, usually with a combination of drugs, such as lamivudine, tenofovir, efavirenz and so on. If the acute phase of AIDS is combined with arthritis, rheumatoid and other diseases, causing generalized wandering pain, in addition to the application of anti-HIV drugs for treatment, but also for arthritis, rheumatoid and other treatments. For the treatment of arthritis, it should start from controlling body weight, strengthening the muscle power and strength exercise of knee joints to reduce the wear and tear of knee joints, and applying anti-inflammatory drugs under the guidance of professional doctors for treatment, such as celecoxib and loxoprofen sodium. If the arthritis is more serious, it should be treated with surgery as soon as possible, such as artificial joint replacement surgery. For the treatment of rheumatoid, it is mainly to take anti-rheumatoid drugs under the guidance of doctors, such as methotrexate, leflunomide, etc., together with glucocorticoids, new biological agents, plant-based drugs for treatment, commonly used drugs are prednisone acetate tablets, methylprednisolone tablets, tumor necrosis factor α antagonists, interleukin 6 monoclonal antibody, tretinoin polyphenol tablets and so on. Once the generalized wandering pain occurs in the acute stage of AIDS, it is recommended to cooperate with professional doctors for examination as soon as possible to find the cause and take symptomatic treatment measures in time.