Duloxetine can usually be taken at bedtime. Duloxetine is duloxetine hydrochloride, is a kind of antidepressant, mainly used for the treatment of generalized anxiety disorder as well as depression, is usually taken during the day, but the patient’s situation is different, some patients can also be taken before bedtime, but it must be guided by the doctor to use the drug. When taking the drug, it should be noted that people who are allergic to the ingredients of the drug are prohibited to take, the drug is prohibited to be combined with monoamine oxidase inhibitors, if you take other drugs during the medication, drug-drug interactions may occur, be sure to consult a doctor. After taking Duloxetine, adverse reactions may occur, such as nausea, dizziness, headache, vomiting, euphoria, etc. If the adverse reactions are obvious, you need to stop taking the drug and consult a doctor.