Bone destruction is the manifestation of many diseases, such as bone tumor lesions, bone infection lesions such as osteomyelitis, etc. Its imaging manifestations are mainly uneven local bone density, sparse bone trabeculae, local bone defects, and bone is worm-eaten, sieve-like, soap-bubble-like, or sunlight-exposed changes. 1. Bone tumor lesions: such as giant cell tumor of bone, osteosarcoma, chondrosarcoma, Ewing’s sarcoma, etc. Generally, bone destruction caused by malignant tumors has unclear boundaries and progresses faster, while bone destruction caused by benign tumors progresses more slowly and has clear boundaries. 2. Bone infection lesions: the most common ones are pyogenic osteomyelitis and bone tuberculosis, etc. Generally, acute infection lesions have more rapid bone destruction and irregular boundary, while chronic infection has relatively clear bone destruction boundary and slow progress. The etiology of bone destruction is more complicated, and some metastases can also cause bone destruction, usually with primary lesions, such as bone metastases from liver cancer, etc. It is recommended that patients should consult doctors for clear diagnosis and follow the doctor’s instructions.