If a patient has pain in both the ankle and the heart of the foot, the following factors should be considered: 1. The factor of infection should be taken into account, for example, the foot is particularly susceptible to infection by bacteria, viruses, fungi or other pathogenic microorganisms, such as mycoplasma and chlamydia. Patients are prone to local cellulitis when infected, which results in symptoms of pain, redness, swelling and heat. 2. Patients with pain in both the ankle and the heart of the foot should consider whether gout is present. For patients with previous hyperuricemia, they are especially prone to gout. 3. Rheumatic and rheumatoid diseases can also cause pain in the ankle and the heart of the foot. 4. If the patient has a previous history of diabetes, consider whether there are symptoms of peripheral neuritis.