The normal range of neutrophil count in normal people is 2~7*10^9/L, so neutrophil count 1.27*10^9/L is neutropenia. Neutrophil count 1.27 etiology may be: 1. immune granulocytopenia; 2. splenomegaly with hypersplenism; 3. viral hepatitis; 4. hematologic disorders and so on.
1. Immune granulocytopenia: immune neutropenia can be caused by: ① systemic lupus erythematosus; ② dry syndrome; ③ connective tissue disease, etc., more common in female patients, need to actively treat the primary disease.
2.. Splenomegaly with hypersplenism: splenomegaly and hypersplenism caused by hepatitis cirrhosis, schistosomal cirrhosis and many other causes can lead to increased destruction of neutrophils, often accompanied by thrombocytopenia.
3. Viral hepatitis: viral hepatitis (type B, type C, etc.) can affect the hematopoietic function of bone marrow, which may lead to neutropenia.
4. Hematologic diseases: Aplastic anemia, multiple myeloma, hypoproliferative acute leukemia and other hematologic diseases can also lead to impairment of the normal hematopoietic function of the bone marrow, which may be manifested as anemia, decreased neutrophil and platelet counts.
Decreased neutrophil count can cause the patient’s autoimmunity to decline, so it is recommended that the patient go to the hematology department in a timely manner, complete the bone marrow aspiration, immunity routine, antinuclear antibody spectrum and other related tests to clarify the causes of neutropenia, and treat the cause of the cause to raise the neutrophil count as soon as possible.