Coffee is a popular drink that can be consumed in moderation to help relieve fatigue, improve mental state, and help improve learning and work efficiency. However, there may be certain precautions in the drinking process, such as trying not to drink at the same time with tea, wine and other stimulating beverages, do not eat with chili, onion, ginger, garlic and other stimulating foods, taking drugs should also avoid drinking coffee. 1, stimulating drinks: coffee should not be consumed at the same time with tea, wine and other stimulating drinks, because the caffeine in coffee, tea polyphenols in tea, alcohol in wine will stimulate the Gastrointestinal tract, which may lead to stomach pain, vomiting and other gastrointestinal discomfort symptoms appear. At the same time, these substances also affect the nervous excitability, which can easily lead to insomnia. In addition, the alcohol in wine will enter the human bloodstream, which itself will affect the human gastrointestinal tract, brain nerves, liver and kidneys, and coffee together may have a greater impact on organ function; 2, stimulating food: chili peppers, onions, ginger, garlic and other spicy and stimulating foods, and coffee in the caffeine mix, will form a more intense stimulation, easily triggering heartburn, stomach pain symptoms; 3, drugs: in taking Any medication at the same time is not recommended to drink coffee. Because coffee may have some effect on the drug, or aggravate the adverse reactions. For example, levothyroxine sodium tablets taken with coffee will reduce its therapeutic effect; aspirin, acetaminophen extended-release tablets and other antipyretic and analgesic drugs and coffee taken together may aggravate the gastrointestinal tract irritation, more likely to stomach bleeding, stomach pain and other discomfort. In addition, vitamins, iron, calcium and other nutritional preparations of drugs, taken with coffee will also reduce the utility. Pay attention to the temperature of coffee, such as hot coffee and cold food, drinks do not eat together, so as to avoid hot and cold stimulation of the gastrointestinal tract, causing abdominal pain, diarrhea. And for pregnant women and children, coffee should be prohibited.