The ingredients of Ambeno are Irbesartan Hydrochlorothiazide, and Benidipine Hydrochloride can be taken together, with synergistic antihypertensive effect. 1. Irbesartan hydrochlorothiazide is a compound preparation, the composition of the drug includes Irbesartan and hydrochlorothiazide, and Benidipine hydrochloride belongs to a different mechanism of the drug, the two drugs can be combined at the same time, increase the effect of blood pressure lowering, and the adverse effects will not significantly increase. 2. Irbesartan hydrochlorothiazide’s main indications are high blood pressure, especially for patients with cardiac insufficiency is effective. Adverse reactions include dizziness, thirst, fatigue, nausea, vomiting, creatinine, transaminase elevation, etc. It is contraindicated in patients who are allergic to the drug components, pregnant and lactating women, and patients with severe hepatic or renal insufficiency. 3. Benidipine hydrochloride is a calcium antagonist antihypertensive drug, adverse reactions include flushing, lower limb edema, dry stools, constipation, etc. It is forbidden for patients who are allergic to the components of the drug, or in cardiogenic shock. Irbesartan hydrochlorothiazide and benadryl hydrochloride should be used under the guidance of a physician when used in combination.