The treatments for early stage lung adenocarcinoma 2.5 cm and invading the pleura include surgery, systemic chemotherapy, radiotherapy, targeted drug therapy and so on. 1. Surgery, mainly thoracoscopic radical surgical resection combined with regional lymph node dissection, is suitable for most of early-stage patients. 2. Systemic chemotherapy, generally about two weeks after the operation can be given to the adjuvant chemotherapy, most of the pemetrexed combined with cisplatin or carboplatin combination program. 3. Radiotherapy is generally suitable for early patients with contraindications to surgery. 4. Targeted drug therapy is mainly suitable for patients with EGFR gene mutation, usually choose gefitinib, erlotinib and so on for treatment, and need to take drugs continuously until the disease progresses. Once diagnosed with early stage lung adenocarcinoma with pleural invasion, it is recommended to consult hospitals and have individualized treatment plans formulated by professional doctors in conjunction with the patient’s condition.