Drug treatment 1.Sodium hyaluronate: It is the main component of synovial fluid in the joint cavity and one of the components of cartilage matrix. It plays a lubricating role in the joint and reduces the friction between tissues. Intra-articular injection can significantly improve the inflammatory reaction of synovial tissue, enhance the viscosity and lubricating function of joint fluid, protect joint cartilage, promote the healing and regeneration of joint cartilage, relieve pain and increase the mobility of the joint. It is often injected intra-articularly, 25mg once, once a week for 5 weeks, and must be operated strictly aseptically. 2.Glucosamine: It is the most important monosaccharide that constitutes polyglucosamine (GS) and proteoglycan in articular cartilage matrix. Normal people can synthesize GS by amination of glucose, but in osteoarthritis, the synthesis of GS in chondrocytes is blocked or insufficient, resulting in softening of cartilage matrix and loss of elasticity, destruction of collagen fiber structure, and increase of cartilage surface lumen to make bone wear and tear. Glucosamine can block the pathogenesis of osteoarthritis, promote the synthesis of proteoglycans with normal structure in chondrocytes, and inhibit the production of enzymes (such as collagenase and phospholipase A2) that damage tissues and cartilage, reduce the damage of chondrocytes, improve joint movement, relieve joint pain, and delay the course of osteoarthritis. Take 250-500mg orally once, 3 times a day, best taken with meals. 3, non-steroidal analgesic anti-inflammatory drugs: can inhibit the synthesis of cyclooxygenase and prostaglandin, counteract the inflammatory response, relieve joint edema and pain. You can use ibuprofen 200-400mg once, 3 times a day; or aminoglycoside zinc 200mg once, 3 times a day; nimesulide 100mg once, 2 times a day for 4-6 weeks. Prevention and health care of osteoarthritis: get more sunshine, pay attention to prevent cold and dampness, keep warm, and make the knee joint get good rest. After the pain is relieved, walk slowly on flat ground once or twice a day for 20-30 minutes each time. Try to reduce up and down steps, running and other exercises that put weight on the knee joint to avoid and reduce the wear and tear of joint cartilage, and when you have to go up and down steps, it is better to hold the stairs or cane.