Megaloblastic anemia is an anemia caused by impaired synthesis of deoxyribonucleic acid (DNA) due to folic acid and/or vitamin B12 deficiency. Causes of folic acid deficiency include: (1) Inadequate intake of fresh vegetables in food, overcooking or pickling can cause loss of folic acid. (2) Increased need for folic acid in women during pregnancy is 5 to 10 times higher than usual. The need for folic acid in growing children and adolescents, chronic hemolysis, leukemia, tumors, hyperthyroidism, skin diseases and patients on long-term hemodialysis treatment is increased, and folic acid deficiency can occur if supplementation is insufficient. (3) Malabsorption Gastric and small intestine resection, celiac disease, restrictive small intestine inflammation, tropical stomatitis diarrhea, etc. can lead to insufficient absorption of folic acid. (4) Drug effects methotrexate, aminoglutethimide, etanercept, phenytoin sodium and luminal can affect the synthesis and absorption of folic acid. Megaloblastic anemia is characterized by an increase in the volume of erythrocytes in peripheral blood, excessive nuclear lobulation of neutrophils (6 or more lobes), which may present as a decrease in whole blood cells and the presence of megaloblasts and megaloblasts in the bone marrow. The clinical manifestations are chronic progressive anemia, loss of appetite, anorexia, abdominal distension, dyspepsia and tongue inflammation and other gastrointestinal symptoms, of which tongue changes are its specific signs: red tongue, papillary atrophy, smooth tongue; there may also be neuropsychiatric symptoms, manifested as weakness, symmetrical numbness of the hands and feet, sensory disorders, unstable gait and walking difficulties in the lower limbs, and children and the elderly often show mental abnormalities after brain damage. Anhedonia, depression, drowsiness, or mental confusion. Megaloblastic anemia is an anemia caused by a deficiency of folic acid and/or vitamin B12, resulting in impaired synthesis of deoxyribonucleic acid (DNA). Causes of folic acid deficiency include: (1) Inadequate intake of food lack of fresh vegetables, overcooking or pickling can cause loss of folic acid. (2) Increased need for folic acid in women during pregnancy is 5 to 10 times higher than usual. The need for folic acid in growing children and adolescents, chronic hemolysis, leukemia, tumors, hyperthyroidism, skin diseases and patients on long-term hemodialysis treatment is increased, and folic acid deficiency can occur if supplementation is insufficient. (3) Malabsorption Gastric and small intestine resection, celiac disease, restrictive small intestine inflammation, tropical stomatitis diarrhea, etc. can lead to insufficient absorption of folic acid. (4) Drug effects methotrexate, aminoglutethimide, etanercept, phenytoin sodium and luminal can affect the synthesis and absorption of folic acid. Megaloblastic anemia is characterized by an increase in the volume of erythrocytes in peripheral blood, excessive nuclear lobulation of neutrophils (6 or more lobes), which may present as a decrease in whole blood cells and the presence of megaloblasts and megaloblasts in the bone marrow. The clinical manifestations are chronic progressive anemia, loss of appetite, anorexia, abdominal distension, dyspepsia and tongue inflammation and other gastrointestinal symptoms, of which tongue changes are its specific signs: red tongue, papillary atrophy, smooth tongue; there may also be neuropsychiatric symptoms, manifested as weakness, symmetrical numbness of the hands and feet, sensory disorders, unstable gait and walking difficulties in the lower limbs, and children and the elderly often show mental abnormalities after brain damage. No desire, depression, drowsiness, or mental confusion.