Patients taking pirfenidone may experience drug-induced liver injury, photosensitivity reactions, gastrointestinal disorders and other adverse reactions after the doctor’s advice to reduce the dosage or stop the drug as appropriate. Common adverse reactions to pirfenidone include jaundice, anorexia, right upper abdominal discomfort, elevated liver enzymes, pharmacologic liver injury, fatigue, deepening of urine color, photosensitivity reaction, rash, abdominal pain, vomiting, dyspepsia, nausea, malaise, gastroesophageal reflux, arthralgia, agranulocytosis, and angioedema. Patients who take pirfenidone after the occurrence of the above adverse reactions, it is recommended that patients communicate with the doctor in a timely manner, reduce the dose of the drug or stop taking the drug, serious patients can be symptomatic supportive treatment. It is recommended that patients go to the regular hospital in time to see a doctor if they feel unwell, and follow the doctor’s instructions for symptomatic treatment.