Urticaria is generally divided into acute urticaria and chronic urticaria, acute urticaria through drug treatment, most patients are not easy to recur, able to cut off the root, while chronic urticaria, the condition is often recurring, cut off the root of the treatment does not exist. Urticaria is mostly related to food or drug allergies, viral or bacterial infections, psycho-neurological factors, autoimmunity, etc. It mainly manifests itself in the appearance of wind clouds or angioedema on the surface of the skin. 1. Acute urticaria: Acute urticaria has a more acute onset, manifested by the appearance of skin eruption-like lesions, usually accompanied by intense itching. It is usually treated with medication, and most patients can be cured. Drug treatment includes oral medication, such as cetirizine, loratadine and other antihistamines, if the patient’s symptoms are severe or accompanied by laryngeal edema, intravenous or intramuscular injection of glucocorticoid drugs, such as dexamethasone. 2. Chronic urticaria: Chronic urticaria refers to patients with urticaria that lasts more than 6 weeks, manifested as irregular skin eruptions or accompanied by erythema, itching and other symptoms. Due to the chronic urticaria cause more, can not be clear, resulting in the condition of often recurring episodes, the course of the delay, can last for months or years, the root cause of the treatment does not exist. Chronic urticaria clinical generally use medication for relief, such as oral antihistamines, including fexofenadine, loratadine, etc.; oral immunosuppressants, such as cyclosporine; oral H2 receptor antagonists, such as cimetidine, etc.; refractory chronic urticaria patients, can be injected with biologics for treatment, such as omalizumab and so on. It is recommended that patients go to the hospital in a timely manner, diagnosed by a professional doctor, according to their own condition to choose the appropriate medication, avoid self-medication, in order to avoid adverse effects.