Rotavirus diarrhea in five-month-old babies is mainly caused by rotavirus infection, which can be relieved by replenishing water and electrolytes as well as antidiarrheal, regulating intestinal flora, adjusting diet and other measures. Rotavirus infection caused by diarrhea symptoms are relatively heavy, it is recommended that five-month-old babies in a timely manner to replenish water, to correct the electrolyte balance disorders, can be relieved by oral rehydration salts, if necessary, need to be given intravenously to quickly relieve the baby’s discomfort, to avoid aggravation of the condition to increase the difficulty of treatment. At the same time, the application of montelukast to protect the baby’s gastrointestinal mucosa, alleviate the symptoms of diarrhea, can also be taken at the same time bifidobacteria triple live bacterial dispersal regulation, to help maintain the balance of intestinal flora. And during the treatment period, we should strictly follow the doctor’s instructions, implement daily care, maintain a light and easy to digest diet, avoid getting cold, if necessary, temporary fasting and water fasting, ensure adequate sleep, etc., which can help to shorten the course of the disease. It is recommended that five-month-old babies with rotavirus diarrhea seek medical attention in a timely manner and be treated aggressively. The above medications should be used in accordance with medical advice.