The specific causes of rheumatoid arthritis are not yet clear, and may be related to genetic and environmental factors. 1. Genetic factors: population survey found that the incidence of rheumatoid arthritis is higher in some families, and there is a link between human leukocyte antigen-DRB1 and human leukocyte antigen-DW4 allele mutation and the development of rheumatoid arthritis. 2. Environmental factors: Environmental factors mainly include occupational exposure, smoking and pathogenic microorganisms. Exposure to silica, asbestos and organic solvents at work may increase the risk of rheumatoid arthritis, and smoking or infection with pathogenic microorganisms such as bacteria, mycoplasma and viruses may also increase the risk of the disease. Rheumatoid arthritis patients are advised to go to the rheumatology and immunology departments of regular hospitals for detailed consultation and standardized treatment as prescribed by doctors.