Epileptic patients long-term medication do not want to eat, want to vomit is mainly due to the side effects of antiepileptic drugs, many antiepileptic drugs can lead to gastrointestinal adverse reactions and hepatic function impairment, common drugs are sodium valproate, carbamazepine, topiramate and so on. 1. Sodium valproate: gastrointestinal reactions among its adverse effects will be nausea, vomiting, stomach pain and diarrhea, elevated aminotransferases and so on. 2. Carbamazepine: common adverse reactions include nystagmus, blurred vision, diplopia and other central nervous system reactions, as well as dizziness, fatigue, nausea and vomiting. 3. Topiramate: adverse reactions such as nausea and anorexia can occur. When epileptic patients appear long-term medication do not want to eat, want to vomit, must not privately stop the drug, also can not privately reduce the dose of medication, so as not to aggravate the condition. It is recommended to consult the hospital in a timely manner, improve liver function, drug blood concentration and other tests, and adjust the drug or other symptomatic treatment under the guidance of the physician.