The common cause of pain during ejaculation is due to prostatitis or vesiculitis. The majority of patients with vesiculitis have a combination of prostatitis, mainly due to incomplete treatment of bacterial prostatitis, and further expansion of bacteria can cause infection of the reproductive tract, commonly due to vesiculitis. The actual painful ejaculation will occur after the vesiculitis is caused. In addition, the patient may have some symptoms of hemorrhagic semen, for this condition, clinical treatment should be actively carried out, should go to urology examination, seminal vesicle ultrasound as well as semen routine can find semen has increased white cells, and seminal vesicle blood rich. For the treatment of seminal vesiculitis, it is generally necessary to use sensitive antibiotics for bactericidal treatment. Commonly used antibiotics are quinolone antibiotics and cephalosporins. Cure the vesiculitis through medication in order to relieve the patient’s painful symptoms during ejaculation.