Hepatoportal cholangiocarcinoma treatments include radical resection, palliative resection, liver transplantation, chemotherapy, targeted drugs and so on. 1. radical tumor resection, including extrahepatic bile duct resection, surrounding tissues, nerves, lymph, etc., even hepatic lobectomy and reconstruction of hepatic duct-jejunostomy. 2. Palliative resection, including left intrahepatic bile duct jejunostomy, right intrahepatic bile duct jejunostomy, tube placement and drainage, etc. 3. Liver transplantation, using in situ liver transplantation, bile duct reconstruction, and parallel choledochotomy and recipient jejunostomy. 4. Chemotherapy, can be preferred to sitagliptin combined with cisplatin treatment. 5. Targeted drugs, as liver cancer is not sensitive to chemotherapy and radiotherapy, targeted drugs such as lenvatinib can be chosen. Hepatoportal cholangiocarcinoma belongs to more difficult to treat tumors, go to the hospital as early as possible and follow the doctor’s advice to choose the appropriate treatment.