Bisoprolol fumarate is a long-acting drug and a beta-blocker with high affinity for beta1 receptors in bronchial and vascular smooth muscle, resulting in vasodilation and lower blood pressure. It is mainly used clinically to control heart rate and treat arrhythmias, and also has a role in the treatment of coronary heart disease, hypertension and heart failure. However, there are contraindications to its application. The most important contraindications must be noted such as slow heart rate, if the ventricular rate is below 50 beats/min, that is, if the basal ventricular rate is below 50 beats/min, in this case bisoprolol fumarate should not be applied. Bisoprolol fumarate should not be used if there is an underlying slow heart rate or arrhythmia, such as atrioventricular block, especially second degree type II atrioventricular block or even third degree atrioventricular block. The maximum recommended dose of bisoprolol fumarate is 10 mg once daily, with a plasma half-life of 10-12 hours after once-daily administration, and can be maintained in plasma for 24 hours. Bisoprolol is excreted in a dual channel, with half being metabolized by the liver as inactive metabolites and then excreted from the kidneys, and the other half being excreted from the kidneys as a prototype drug. Since the drug is cleared from the kidneys and liver in equal proportions, no dose adjustment is required in patients with mild to moderate hepatic or renal abnormalities.