In advanced stage of liver cancer, severe decline of liver function, stimulation of gastrointestinal tract by jaundice and advanced liver cancer and ascites may compress the stomach and intestines and appear tumor metastasis, which will make the appetite decrease. In advanced stage of liver cancer, liver function decreases seriously and jaundice will cause stimulation to gastrointestinal tract, which will make patients lose appetite; liver cancer encroaches a large amount of effective volume of liver, and enlarged liver may compress stomach, making limited space for stomach; intestines may also have obstruction caused by tumor compression or metastasis, which will lead to poor appetite and reduced food intake. In addition, a large amount of ascites compresses the gastrointestinal tract, and the obstruction of intestinal venous return in portal hypertension leads to edema of the gastrointestinal tract and poor peristaltic function, which also leads to loss of appetite and inability to eat. Hepatocellular carcinoma patients should pay attention to develop good living habits and dietary habits, try to eat less and more meals, and do not overeat. If poor appetite persists they should report to the doctor.