Isotretinoin should not be taken during alcohol consumption, it may increase the toxic side effects of the drug, as well as aggravate the damage to the liver caused by alcohol. Isotretinoin is indicated for severe refractory nodular acne with established adverse effects, mainly skin rashes, conjunctivitis, osteoporosis, thinning of hair, hepatitis, pancreatitis and bleeding gums. If taken during alcohol consumption, the toxic side effects of the drug are aggravated, which seriously affects the therapeutic effect of the drug. At the same time, the drug will aggravate the damage of alcohol to the human liver, and even serious adverse reactions. Isotretinoin is prohibited for use in women who are pregnant or about to become pregnant. Women of childbearing age or their spouses should use effective contraception 3 months before starting treatment with Isotretinoin, during treatment and 3 months after stopping the drug. If you need to stop smoking or drinking alcohol during the medication period, and if you need to take other medications orally at the same time, you must take them under the guidance of your doctor. Isotretinoin medication need to follow the doctor’s instructions, after the treatment has no effect or symptoms worsened, you need to stop using the drug, timely medical treatment, to avoid delaying the condition. Do not blindly use your own medication.