Whether ankylosing spondylitis requires long-term use of Liuzosulfapyridine needs to be judged according to the patient’s condition and efficacy, etc., and cannot be generalized. Ankylosing spondylitis generally does not affect life expectancy, but it is incurable, and most patients need long-term medication to improve their symptoms and slow down the progression of the disease. Patients can follow the doctor’s instructions to use salicylazosulfapyridine for treatment, which can improve joint pain, swelling and stiffness, etc., and can also improve the patient’s peripheral arthritis. Whether ankylosing spondylitis patients need long-term use of sulfasalazine should be judged according to the patient’s condition and therapeutic effect, if the patient’s treatment with the drug is better, generally can be used for long-term treatment, if the treatment effect is not good, it is not suitable for long-term use of the drug. If the treatment effect is not good, it is not suitable for long-term use. And the drug is prohibited for patients who are allergic to sulfonamide. Patients need to strictly under the guidance of the doctor to take the drug reasonably, if combined with other drugs, but also need to consult the doctor. It is recommended that patients with ankylosing spondylitis actively cooperate with rheumatologists to carry out drug treatment, and follow the doctor’s instructions for the use of salazosulfapyridine.