For patients for whom indications exist, Sacubitril valsartan is taken at a minimum of 100mg per day, and the exact dosage of the drug needs to be decided by the doctor after a comprehensive assessment in conjunction with the condition. Sacubitril valsartan belongs to the compound preparation, which is mainly used for the treatment of chronic heart failure with reduced ejection fraction, and usually the drug may affect the liver and kidney function in the process of taking. Therefore, for patients with moderate hepatic and renal impairment, as well as patients with systolic blood pressure of 100~110mmHg, patients who have not taken ACEI or angiotensin II receptor antagonist, the daily dose is at least 100mg, and should be divided into two times in the morning and evening, while the other groups of people take a minimum of 200mg per day, also divided into two times. Normally, the drug may cause abnormalities in hemoglobin, hematocrit, creatinine, serum potassium, etc.; it is forbidden for those who are allergic to the ingredients of the drug, those with angioedema, and those with severe liver or kidney impairment; and blood pressure, liver or kidney function and electrolytes need to be monitored during the course of taking the drug. All of the above medications should be used under the guidance of a doctor, avoiding self-medication, so as to avoid adverse consequences.