After taking sertraline, the condition is stable for more than one year and the symptoms have improved, you can consider reducing the medication, and depending on the condition during the reduction period, you can decide whether to continue the reduction or stop the medication. Sertraline is mainly used to treat depression. Treatment with antidepressant drugs must be adequate in dose and duration, and must not be stopped suddenly, otherwise it may easily cause somatic discomfort or lead to relapse of the disease. If the depressive symptoms disappear completely, while the social function is fully restored, and the maintenance state treatment is more than one year without any recurrence of symptoms, you can consider reducing the drug dosage. Before reducing the medication, you should go to the psychiatric department of the hospital for a follow-up consultation, and only after the physician’s professional assessment and consent, you can start to reduce the medication. It is also important to follow the principle of small and slow doses during the reduction period, and not to be too hasty. It should be noted that spring and autumn are the seasons when depression is prone to relapse, so try to avoid reducing or stopping medication in spring and autumn.