Possible causes of pain in the urethra: 1. Prepuce and glansitis can cause pain in the urethral orifice or cause pain in the front of the urethra. The appearance can be seen as redness and swelling around the urethral orifice and vesicles, or with the exudation of secretions around the disease. 2, urethritis or cystitis, can appear pain in the urethra, when inflammation occurs so that the urethral mucosa is acutely congested and edematous, which is can appear localized erosion, causing pain during urination, or a vague painful feeling in the urethra. 3, if there are stones in the urethra, it can cause persistent stabbing pain in the urethra 4. polyps or tumors in the urethra can cause pain in the urethra and cause a feeling of foreign body or obstruction in the urethra, which can be accompanied by bleeding from the urethra and requires urethroscopy to confirm the diagnosis. 5. sexually transmitted diseases such as gonorrhea and non-gonococcal urethritis can cause pain in the urethra, accompanied by yellow-purulent discharge from the urethra. purulent discharge.