Primary hyperuricemia is usually the result of impaired purine metabolism. Blood uric acid levels are closely related to the rate at which the body re-synthesizes purines, and ribulose phosphate pyrophosphate synthase (PRPP) plays an important role. Enhanced phosphoribosyl pyrophosphate synthase (PRPP) activity and reduced hypoxanthine phosphoribosyltransferase (HPRT) activity are two concomitantly inherited defects in purine metabolism that cause excessive purine production, hyperuricemia, and hyperuricosuria. Patients with primary hyperuricemia pay attention to controlling purine intake in their lives, avoiding high-purine foods, such as seafood, animal offal, thick meat soup, etc., and drinking more water to promote uric acid discharge. When patients appear primary high uric acid, it is recommended to go to the hospital in time for consultation, after clarifying the cause of the disease, and under the guidance of the doctor’s advice for treatment.