White pimple-like substances appearing at the corners of the mouth may be caused by acne, milia, sebaceous gland ectasia and other diseases, and patients are advised to remove them through medication, laser or freezing after clarifying the specific cause under the guidance of a doctor. 1. Acne: Acne will have the symptom of whiteheads, which may be formed due to exuberant oil secretion and abnormal keratinization of the cells at the opening of the sebaceous glands of the hair follicles. Patients should follow the doctor’s instructions to remove them with topical medications such as adapalene gel and other retinoids and benzoyl peroxide gel. 2. Corns: The cause of corns is not known, usually no treatment is needed, and it can subside by itself; if it affects the aesthetics or has the need for treatment, it can be removed by electric drying method and laser treatment under the guidance of doctors. 3. Sebaceous gland ectasia: the cause of this disease is not known, will not affect health, usually without treatment; patients with treatment needs, you can follow the doctor’s instructions to use laser treatment, electrocoagulation treatment, surgical treatment and other ways to remove. White acne-like substances appearing at the corners of the mouth may also be caused by other diseases, and it is recommended that patients go to a regular hospital in time for examination and active diagnosis and treatment. The above drugs need to be standardized treatment under the guidance of a professional doctor.