The 45-year-old woman’s irritability before menstruation may be a normal phenomenon, or it may be considered to be related to premenstrual tension syndrome. 1. Normal phenomenon: women’s hormone levels will change before menstruation, there may be mood swings, some patients may be anxious and depressed, insomnia and forgetfulness, etc., after the end of menstruation, the symptoms can gradually disappear, it is a normal phenomenon, generally do not need special treatment. 2. Premenstrual tension syndrome: Premenstrual tension syndrome can occur in adolescence, and some women may not develop or aggravate until they are more than 30 or 40 years old. Physical symptoms, such as headache, breast swelling and pain, may also occur, as well as mood changes such as anger, irritability and anxiety. If the patient’s symptoms are more obvious and have already affected daily life, it is recommended to go to the gynecology department of the hospital, and if necessary, medication will be given under the guidance of the doctor to regulate.