Generally, comatose patients may wake up with increased unconscious movements of the eyes or limbs, stabilized vital signs and avoidance response to painful stimuli. It is recommended to have a professional physician to judge the patient’s conscious state. 1. Increase in unconscious movements: unconscious patients may gradually recover to a state of minimal consciousness, mainly manifested by an increase in unconscious movements, such as letting go of the hand, shaking hands, blinking, and turning the head. 2. Stable vital signs: when the vital signs of comatose patients such as respiration, heart rate and blood pressure are stable, and the indicators of blood routine, biochemistry, liver and kidney function, electrolytes and so on are normal, it also suggests that the patient’s condition is stable, and there is a possibility of awakening. 3. Avoidance response to pain stimulation: when comatose patients have avoidance response to sound, light, pain and other stimuli, it may also suggest that the patient’s consciousness level improves, which may be the performance before waking up. Comatose patients should also pay attention to strengthen the nursing care, strengthen the turn over and pat the back, timely sputum suction, to avoid prolonged lying in bed with various complications, such as accumulation of pneumonia decubitus ulcers and urinary tract infections and so on.