Pituitary crises is one of the acute and critical conditions in endocrinology, which often occurs under stressful conditions. The clinical manifestations are hypogonadism of different degrees, such as loss of libido, beard reduction, loss of body hair, female menopause and breast atrophy; at the same time, there are signs of insufficient secretion of thyroid hormone, such as cold and weakness, pale and less elastic skin, indifferent expression, and slow movement. Hypotension, hypoglycemia, coma, temperature failure, anemia, and shock occurred. The average blood glucose was 2.4 mmol/L, the lowest was 0.8mmol/L, the average blood sodium was 122 mmol/L, the lowest was 109 mmol/L, and the body temperature was 35 ℃, which showed a mixed type, water intoxication type, and circulatory failure type pituitary crisis. Treatment of pituitary crisis: First, give intravenous push of 50% glucose solution 40-60 ml to rescue hypoglycemia, followed by 10% glucose saline, and add hydrocortisone 50-100 mg intravenous per 500-1000 ml to relieve acute hyperalgesia crisis. Those with circulatory failure should be treated according to the principles of shock, those with infectious sepsis should be treated with active anti-infection, and those with water intoxication should mainly be treated with enhanced diuresis, and prednisone or hydrocortisone can be given. Hypothermia is related to hypothyroidism, so small doses of thyroid hormone can be given and warmed up gradually with a warming blanket. Use of anesthetics, sedatives, hypnotics or hypoglycemic drugs is prohibited or used with caution. Once the diagnosis of pituitary crisis is made, hydrocortisone 200-300 mg/d intravenous drip should be given immediately, and the dose should be gradually reduced after the condition is stabilized. During the course of treatment, attention should be paid to anti-infection, anti-shock and symptomatic support therapy, and changes in blood pressure, body temperature, blood glucose and blood sodium, etc. After the crisis period, small doses of thyroid hormone therapy should be added and gradually increased to the required maintenance amount. In the case of hypothermic pituitary crisis, thyroid hormone is administered as soon as possible. In the case of women of childbearing age, oral artificial cycle medication is also added to maintain secondary sexual characteristics and a high quality of life. There was no significant difference in the amount of glucose and sodium supplementation within 48 h of long-term hormone replacement therapy after active resuscitation, but there was a significant difference in the amount of glucocorticoids and the time to correction of hyponatremia. The mean dosage of hydrocortisone was larger, 400 (300-600) mg, and the hyponatremia was more obvious, with a mean of 110 (105-115) mmol/L. The hyponatremia was corrected more quickly In about 48 hours. All deaths were combined with multi-organ failure, and all had serious infections. Generally, 40-60 ml of 50% glucose should be injected, followed by 500-1000 ml of 10% glucose and 100-300 mg of hydrocortisone drip, but the dosage of hydrocortisone should not be too large in hypothermic coma. Second, hypothermic type: treatment is similar to that of mucinous edema coma, but attention must be paid to the addition of appropriate amount of hydrocortisone before (or at least simultaneously) with thyroid hormone. In addition, the use of central depressants such as chlorpromazine and barbiturates is strictly prohibited. (3) Sodium loss coma: Sodium-containing fluids must be supplemented in the same way as for adrenal crisis. Water intoxication coma: Give small to medium amount of glucocorticoids immediately and restrict water. V. Pituitary stroke: large amounts of hormone replacement therapy, hemostatic agents, etc. should be given. Those with uremia or abnormal secretion of antidiuretic hormone should be tested for water and salt metabolism; in case of severe cranial pressure increase, vision loss, coma, and progressive deterioration, surgical decompression should be performed.