The causes of high absolute value of naïve granulocytes include leukemia, myelodysplastic syndrome, myelofibrosis and so on. Before treatment, it is first necessary to improve the relevant examination to clarify the cause of the disease, and then carry out the treatment for the cause. 1. Leukemia: Leukemia is divided into acute and chronic leukemia. The treatment for acute leukemia is usually chemotherapy (cytarabine, zithromax). Chronic leukemia can be treated with tyrosine kinase inhibitors such as imatinib under doctor’s supervision. 2. Myelodysplastic syndromes: low and intermediate risk patients are treated with supportive therapy, pro-hematopoietic (erythropoietin), demethylating drugs (decitabine) and immunomodulators (lenalidomide) to improve hematopoiesis. Intermediate and high-risk patients are treated with methylating drugs, chemotherapy (cytarabine) and hematopoietic stem cell transplantation to improve the natural course of the disease. 3. Myelofibrosis: Targeted treatment is carried out according to the degree of bone fiber proliferation and clinical manifestations of patients. The treatment is generally based on correcting anemia, inhibiting cell proliferation (hydroxyurea) and improving bone marrow hematopoiesis (rucotinib). If the absolute value of naïve granulocytes is high in the examination, the patient should consult the doctor in time to clarify the cause of the disease, and use medication under the guidance of the doctor to avoid delaying the condition.