Nausea when pressing on the epigastrium may be related to indigestion, gastrointestinal dysfunction, chronic superficial gastritis, etc., and is usually treated with general therapy and medication. 1. Dyspepsia: often manifested as epigastric pain, epigastric burning sensation, epigastric fullness, etc., which may lead to nausea when holding the epigastrium. It is recommended to give drugs to inhibit gastric acid such as proton pump inhibitor omeprazole, etc., promote gastrointestinal dynamics such as mosapride, cinitapride, etc., and promote digestion such as digestive enzyme tablets. 2. Gastrointestinal dysfunction: often manifested as abdominal pain, diarrhea, nausea, etc., which may lead to nausea when holding the upper abdomen. It is recommended to give gastric stimulants such as domperidone, antispasmodic drugs such as scopolamine, antidiarrheal drugs such as loperamide, probiotics and so on. 3. Chronic superficial gastritis: often manifested as abdominal pain, abdominal distension, postprandial fullness, etc., which may lead to nausea when holding the upper abdomen. It is recommended to give drugs to inhibit gastric acid such as lansoprazole, cimetidine, etc., gastric mucosal protective agents such as colloidal bismuth, bismuth potassium citrate, etc., and gastric power drugs such as itopride. Pressing the epigastric nausea, there may be many other reasons, if the above symptoms, it is recommended to choose to find out the cause of medical treatment, follow the doctor’s instructions for targeted treatment, do not unauthorized use of drugs.