The effect of taking glutamine plus vitamin B12 twice a day is mainly determined by the cause of the disease, the severity of the disease, the patient’s own situation and other factors, the effect of the use of individual differences. The use of glutamine and vitamin B12 together is mainly used for the nutrition of the nerves, and has the effect of regulating autonomic dysfunction. The effect of the treatment is mainly affected by the cause of the disease, the severity of the disease, the patient’s own condition and other factors, the effect of the use of individual differences. The use of the two drugs may cause nausea, vomiting, dry mouth, low potassium, stomach upset and other adverse reactions. Glutamine should be used with caution in patients with gastric and duodenal ulcers. Vitamin B12 should be used with caution in patients with glaucoma, patients with gout, and patients with Lieber’s disease. Contraindications for both drugs are unclear. The combined use of these two drugs must follow the doctor’s instructions, do not blindly use their own drugs, so as not to cause adverse consequences.