Interstitial cystitis lacks effective treatment, currently commonly used drugs include oral drugs immunosuppressant hydrocortisone, antihistamines such as treponemal, heparin, pentosan sulfate sodium, etc. and bladder perfusion drugs such as silver nitrate and dimethyl sulfoxide. 1.Drug treatment (1) Immunosuppressive drugs: such as hydrocortisone or prednisone, azathioprine. (2) Antihistamines: such as trimethoprim. (3) Heparin: can neutralize eosinophilic cationic proteins, generally 12h after the use of drugs to reduce symptoms. Long-acting heparin 20,000U can also be injected intravenously to block the effect of histamine. (4) Sodium pentosan sulfate: it can replenish the missing amino glucan of bladder mucosa. (5) Other: vitamin E; anti-connective tissue drugs, chloroquine; in addition to estrogen, amitriptyline, anticholinergics, antispasmodic and analgesic drugs, calcium channel blocking drugs. 2. Bladder perfusion drugs (1) silver nitrate: with the use of bupivacaine, retained for 4 min after release, can achieve better results. (2) 50% dimethyl sulfoxide (dimethyl sulfoxide) 50 ml injected into the bladder, twice a week, each time retained for 15 min, with better results with corticosteroids. (3) Hydrocortisone or heparin is injected around the ulcer via cystoscopy, which can expand the bladder capacity and relieve symptoms. When it is difficult to control the symptoms with medication or when the bladder capacity shrinks to less than 150 ml, surgical treatment is needed. After the diagnosis of interstitial cystitis is confirmed, medication should be used rationally and treatment standardized under the guidance of a specialist.