Chalazion and granuloma are different in terms of causes, clinical symptoms and treatment methods. 1. Pathogenesis: chalazion is caused by the obstruction of the outlet of the lid gland, resulting in the retention of secretions to form cysts, belonging to the idiopathic chronic non-suppurative inflammation of the lid gland, which is related to chronic conjunctivitis, blepharitis, sebaceous glands and sweat glands with exuberant secretion function and other factors. Chalazion is an acute purulent inflammatory lesion of the eyelid glands, mainly caused by staphylococcal infection. 2. Clinical symptoms: chalazion is mainly characterized by a lump on the eyelid, or accompanied by foreign body sensation, blurred vision and other symptoms, a few secondary infections before redness, swelling, pain and other symptoms. Chalazion is usually characterized by redness, swelling, heat and pain. External blepharitis has hard nodules at the red and swollen areas, which are painful when pressed, while internal blepharitis has yellow pus spots at the lid conjunctiva and breaks down into the conjunctival sac. 3. Treatment: chalazion usually requires surgical resection, and can be relieved by hot compresses in the early stage. Early stage of chalazion can be relieved by localized hot compresses, antibiotic eye drops or eye ointment (e.g. levofloxacin eye drops, erythromycin eye ointment, etc.), severe cases need oral cephalosporin antibiotics (occasionally gastrointestinal irritation) for treatment, and surgical drainage of intractable abscesses can be considered. The specific treatment of chalazion and granuloma must be under the guidance of the doctor’s medication, not self-medication.