The causes of frequent headaches in 16-year-old high school students may include tension headache, migraine, cluster headache, intracranial tumor and so on. 1. Tension headache: it is a common cause of headache in young people. High school students’ high study pressure and high mental tension may cause tension headache. In addition, stress, depression and tension can also cause persistent scalp muscle contraction and aggravate headache. 2. Migraine: It may be related to genetic factors, or induced by environmental factors or certain medicines or foods. Overwork, stress, excessive or insufficient sleep, etc. are also causes of migraine. 3. Cluster headache: It is a primary trigeminal autonomic headache with circadian rhythm. It may be caused by hypothalamic dysfunction. 4. Intracranial tumor: intracranial tumor grows and compresses normal brain tissue and nerves, causing headache, you can perform cranial magnetic resonance examination for the presence of intracranial tumor. Frequent headaches in 16-year-old high school students may also be caused by other reasons, it is recommended to consult a doctor in a timely manner to clarify the cause of the symptomatic treatment.