Women 45 years old completely no libido, may be some physiological phenomenon, may also be the manifestation of certain diseases, such as perimenopausal syndrome, premature ovarian failure, etc., should be timely consultation to identify the cause of the disease. 1. Physiological factors: due to sexual disharmony or too much mental stress, etc., may cause a decline in libido, or even no libido at all. 2. Pathologic factors: (1) Perimenopausal syndrome: it may be due to the decline of ovarian function, the gradual decline of sex hormone level, and the subsequent series of changes in the body’s neuroendocrine system, thus triggering a series of clinical symptoms, such as decreased libido, menstrual abnormality, hot flashes, agitation and irritability. (2) Premature ovarian failure leads to a decline in estrogen levels, and a long-term decline in estrogen levels will result in a decrease in secretions and a thinning of the vaginal mucosa, which can lead to a lack of libido. Usually, women’s libido will gradually decline after 45, but other reasons cannot be ruled out. It is recommended that the patient should consult a doctor in time to clarify the cause and give targeted treatment.