The treatment of motor nerve demyelination combined with axonal damage includes etiologic treatment and symptomatic treatment. 1. Etiological treatment: if paraneoplastic nerve damage is caused by tumor, surgical resection of the tumor is needed; if it is caused by long-term alcoholism, strict abstinence from alcohol should be given; if it is caused by medication, drugs should be discontinued and so on. If it is caused by immune-related factors, hormone or immunoglobulin, immunosuppressant treatment should be given. 2. Symptomatic treatment: Vitamin B, methylcobalamin and other nutritive nerve drugs can be given for symptomatic treatment; those who affect the function of limbs can be given functional rehabilitation treatment; they can also be given with acupuncture, physiotherapy and other treatments to promote functional recovery. The combination of motor nerve demyelination and axonal damage suggests that motor nerve sensory and motor involvement, and timely consultation is needed to further define the cause of the disease and timely treatment, so as to avoid delaying the condition and affecting the prognosis.