The treatment of megaloblastic anemia is as follows: 1. General treatment: that is, treating the underlying disease, removing the cause, enhancing education on nutrition, correcting partial eating and poor cooking habits (avoiding prolonged cooking); 2. Supplementary treatment: according to the principle of what is lacking is supplemented, adequate amounts of folic acid and vitamin B12 should be supplemented until the proper stores are replenished. Folic acid deficiency is generally selected from oral folic acid tablets, 5-10mg, 3 times a day; for patients with absorption disorders, intramuscular injection of calcium tetrahydrofolate, 3-6mg intramuscular injection, once a day, until the blood picture is completely restored; if accompanied by vitamin B12 deficiency, simple folic acid can aggravate the symptoms of the nervous system, and should be combined with vitamin B12; vitamin B12 deficiency on intramuscular injection of vitamin B12 If vitamin B12 deficiency is accompanied by neurological symptoms, prolonged, high-dose treatment is required. For patients with simple B12 deficiency, treatment with folic acid alone is inappropriate, as it may aggravate the vitamin B12 deficiency, especially if neurological symptoms occur or are aggravated.